Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Courelli et al., Cell Mol Bioeng. 2021 Aug 13;14(6):583-596

Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance

Kuo et al., Sci Rep. 2020 Feb 3;10(1):1725. doi: 10.1038/s41598-020-58361-4.

Cleavage of the leptin receptor by matrix metalloproteinase-2 promotes leptin resistance and obesity in mice

Mazor et al., Sci Transl Med . 2018 Aug 22;10(455):eaah6324

Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock

Santamaria et al., J Trauma Acute Care Surg . 2017 Aug;83(2):263-270

Autodigestion: Proteolytic Degradation and Multiple Organ Failure in Shock

Altshuler et al., Shock. 2016 May;45(5):483-9

The Autodigestion Hypothesis for Shock and Multi-Organ Failure

Schmid-Schönbein and Chang. Ann Biomed Eng. 2014 Feb;42(2):405-14

Pancreatic Digestive Enzyme Blockade in the Intestine Increases Survival After Experimental Shock

DeLano et al., Sci Transl Med. 2013 Jan 23;5(169):169ra11

2008 Landis Award Lecture Inflammation and the Autodigestion Hypothesis

Schmid-Schönbein. Microcirculation. 2009 May;16(4):289-306