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Science

Palisade Bio is leveraging more than three decades of academic research as well as 15 years of the company’s own internal efforts to advance therapies that help patients with acute and chronic gastrointestinal complications stemming from post-operative digestive enzyme damage.

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LB1148

Lead drug candidate LB1148 is a phase 3-ready, oral drug with the potential to both reduce abdominal adhesions and help restore bowel function following surgery, two complications that increase the time patients spend in hospitals. LB1148 has pipeline-in-a-product potential, given the array of various complications downstream of digestive enzyme damage that could be addressed by preserving intestinal integrity.

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Guarding Intestinal Integrity

More than 30 years of groundbreaking scientific research conducted at the University of California at San Diego and other prestigious academic institutions supports the importance of guarding intestinal integrity to overall human health and highlights the medical complications that can occur when its intestinal mucosal barrier is disrupted.

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Palisade Bio is a late-stage biopharma company advancing therapies that help patients with acute and chronic gastrointestinal complications stemming from post-operative digestive enzyme damage. Lead asset LB1148 is a Phase 3-ready protease inhibitor with potential to both reduce abdominal adhesions and help restore bowel function following surgery. Positive data from Phase 2 trials of LB1148 demonstrated safety and tolerability as well as a statistically significant improvement in return to bowel function and decrease in length of stay in ICU and hospital compared to placebo.